DISSERTATION TOPIC

 TITLE:-

Managing sarcopenia and visceral fat driven vascular outcomes in patients with diabetes 


Problem statement/Background:

"Although obesity-related type 2 diabetes mellitus (T2DM) and sarcopenia have been increasing worldwide, the associations among visceral fat accumulation, skeletal muscle indices (mass, strength, and quality) and vascular outcomes in T2DM remain poorly investigated."

Quoted from reference 1 : https://cardiab.biomedcentral.com/articles/10.1186/s12933-018-0755-3

Even while it's easy to qualitatively spot individuals with reduced limb muscle mass and trunkal fat it is important to establish that improving limb muscle mass and reducing trunkal fat utilizing diet and exercise strategies would improve cardiovascular outcomes in patients with diabetes mellitus. 

AIM:

To improve vascular outcomes in patients at risk of diabetes evidenced by their increased visceral fat and reduced muscle mass and strength  

OBJECTIVES:

• To assess various clinical and investigational characteristics of patients with Sarcopenia and diabetes in relation to their outcomes.

• To analyse patient outcomes based on morbidity (physical, social & psychological limitations) & mortality.


PATIENTS AND METHODS:

PLACE OF STUDY: Department of General medicine , Kamineni Institute of Medical Sciences, Narketpally.

STUDY PERIOD: November 2022- October 2024

STUDY DESIGN : Non experimental (Observational) qualitative Prospective Study 

SAMPLE SIZE: 50 patients 

INCLUSION CRITERIA:

• Patients of any gender above or equal to 18yrs of age at the time of presentation.

• Patients presenting with a combination of sarcopenia and increased visceral fat with or without diabetes mellitus 


EXCLUSION CRITERIA:

1.Patients below 18 yrs of age (minors)

2.Patients not capable of giving consent (mentally-ill patients)

3.Patients not willing to participate in study (non-consenting patients)

PROFORMA (data to be captured) 

Demographics

Anthropometric indicators of sarcopenia and increased visceral fat :

Mid arm circumference 

Abdominal circumference 

Functional indices :

Hand grip 

Biceps power 

On investigation :
  • FBS, PPBS, Hba1c
  • Chest X-ray -PA view
  • ECG
  • 2D ECHO
  • CBP
  • Serum creatinine 
Patient reported outcomes :

Daily exercise (in terms of routine activities)

Daily diet in the form of meal images captured before consumption 

Blood sugar outcomes in terms of weekly FBS ppbs and Hba1c every three months

Vascular outcomes suggested by symptoms and signs of vascular events involving different organ systems supplied by macro and micro vessels such as cardiac, neurological, renal, ocular, cutaneous etc. 


REFERENCES:-

Saeedi, P.; Petersohn, I.; Salpea, P.; Malanda, B.; Karuranga, S.; Unwin, N.; Colagiuri, S.; Guariguata, L.; Motala, A.A.; Ogurtsova,
K.; et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the
International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res. Clin. Pract. 2019, 157, 107843. [CrossRef]

2. Umegaki, H. Sarcopenia and frailty in older patients with diabetes mellitus. Geriatr. Gerontol. Int. 2016, 16, 293–299. [CrossRef]

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IDF diabetes atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res. Clin. Pract. 2017, 128, 40–50.
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4. American Diabetes Association. 12. Older adults: Standards of Medical Care in Diabetes-2019. Diabetes Care 2019, 42, S139–S147.
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5. Kirkman, M.S.; Briscoe, V.S.; Clark, N.; Florez, H.; Haas, L.B.; Halter, J.B.; Huang, E.S.; Korytkowski, M.T.; Munshi, M.N.; Odegard,
P.S.; et al. Diabetes in older adults. Diabetes Care 2012, 35, 2650–2664. [CrossRef]

6. Liccini, A.; Malmstrom, T.K. Frailty and Sarcopenia as Predictors of Adverse Health Outcomes in Persons with Diabetes Mellitus.
J. Am. Med. Dir. Assoc. 2016, 17, 846–851. [CrossRef] [PubMed]

7. Rosenberg, I.H. Sarcopenia: Origins and clinical relevance. J. Nutr. 1997, 127, 990S–991S. [CrossRef]

8. Baumgartner, R.N.; Koehler, K.M.; Gallagher, D.; Romero, L.; Heymsfield, S.B.; Ross, R.R.; Garry, P.J.; Lindeman, R.D. Epidemiol￾ogy of sarcopenia among the elderly in New Mexico. Am. J. Epidemiol. 1998, 147, 755–763. [CrossRef]

9. Filippin, L.I.; Teixeira, V.N.; da Silva, M.P.; Miraglia, F.; da Silva, F.S. Sarcopenia: A predictor of mortality and the need for early
diagnosis and intervention. Aging Clin. Exp. Res. 2015, 27, 249–254. [CrossRef]

10. Goodpaster, B.H.; Park, S.W.; Harris, T.B.; Kritchevsky, S.B.; Nevitt, M.; Schwartz, A.V.; Simonsick, E.M.; Tylavsky, F.A.; Visser, M.;
Newman, A.B. The loss of skeletal muscle strength, mass, and quality in older adults: The health, aging and body composition
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11.  Cruz-Jentoft, A.J.; Baeyens, J.P.; Bauer, J.M.; Boirie, Y.; Cederholm, T.; Landi, F.; Martin, F.C.; Michel, J.P.; Rolland, Y.; Schneider,
S.M.; et al. European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis:
Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010, 39, 412–423. [CrossRef] [PubMed]



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